Medical Drugs Articles
-
Supporting Veterinary Resilience for World Veterinary Day
April 30th is World Veterinary Day. Taking place each year on the last Saturday of April, World Veterinary Day was created in 2000 by the World Veterinary Association as an annual celebration of the veterinary profession. Each year, there is a new theme. You can read about last year’s theme here. This year, the theme is Strengthening Veterinary Resilience. ...
-
In the NFL `Afterlife` everything hurts
Not too long ago in the August 4th version of the San Jose Mercury News, reporter Elliott Almond caught up with NFL Hall-of-Fame quarterback Jim Plunkett to talk about life after football. His response made headlines. "My life sucks", said Plunkett, now 69. "It’s no fun being in this body right now. Everything hurts." The years of daily pain pulsating from the neck, back, knees, ...
-
The Endocannabinoid System, A Physician`s Perspective
Most physicians are constantly learning not only for their benefit but, more importantly, for the benefit of their patients. It is not surprising therefore that there is considerable interest in the endocannabinoid system (ECS) as this system has only been recently recognized and appreciated. I think it is fair to say that over the last decade there has been more interest in the ECS than any ...
-
Pain and the Endocannabinoid System, A Physicians Perspective
The topic of pain and pain control is a very complex one with many different areas of concern and consideration. I will try to outline this complex topic as it applies to the endocannabinoid system. In my last article I briefly outlined this system and described it as an internal “buffer” the main function of which is to create homeostasis within our body. When considering the ...
-
Silk Fibroin Enhances Tendon Repair and Tissue Regeneration
Researchers at the Terasaki Institute for Biomedical Innovation have used silk protein, which is produced by silkworms, as a biomaterial for tendon repair. The researchers report that their approach has made significant progress in tendon regeneration of mesenchymal stem cells (MSCs). SF is a promising biomaterial for tendon repair, but its relatively rigid mechanical properties and low cell ...
By Matexcel
-
Mutation-directed Neo-protein-protein Interactions in Cancer
Genetic mutations in cells are an important cause of cancer development, progression, and drug resistance. How to quickly and accurately translate massive tumor genomic information into safe and effective cancer targeted therapies in clinical practice is a scientific frontier today. At present, a large number of scientific studies have focused on how oncogenic mutations regulate the activity of ...
By Profacgen
-
Enzymatic Mechanism by Which Dolphin Gut Microbes Degrade Plant Polysaccharides Unveiled
Symbiotic microbial groups within the digestive tract of herbivores are the main source of depolymerized lignocellulases. The dolphin is the largest extant rodent, usually living in the Pantanal wetland and Amazon basin, and is also known as the "king of grass" due to its diet based on grasses and aquatic plants. They can efficiently depolymerize and utilize lignocellulosic biomass through ...
By CD BioGlyco.
-
A Novel Potential Target for CAR-T Cell Therapy in Human Solid Tumors Discovered
At present, chimeric antigen receptor T cell therapy (CAR-T) has made significant achievements in the treatment of specific hematological cancers, allowing patients with relapsed/refractory disease to survive longer and become healthier, but in clinical studies, cell therapy has actually not been successful in the treatment of patients with solid tumors, in part due to the lack of tumor targets ...
-
Near-atomic-level Details of Cancer Proteins with the Help of Molecular Cages Revealed
Sandwiching the wobble protein between two other layers allowed scientists to get the most detailed picture of a protein that is key to the spread of acute myeloid leukemia. Acute myeloid leukemia (AML) afflicts more than 20,000 Americans each year, killing more than 11,000 of them, according to the American Cancer Institute. And many people who receive intensive chemotherapy or stem cell ...
-
Therapeutic Massage for Arthritis in Pets
As most of you know by now, arthritis is one of the most common diseases that afflicts pets. In fact, according to most estimates, 1 in 5 dogs is affected by osteoarthritis. Additionally, it is estimated that 40-92% of cats are affected by arthritis. There are numerous potential treatment modalities for arthritis including medications, rehabilitation, and even VetStem Cell Therapy. Another ...
-
Bioinformatics Analysis Brings Disease Genomics Research to a Crossroads
Introduction Since the completion of the Human Genome Project, genomics has played an increasingly critical role in the biomedical field. Its applications include variation and risk assessment in disease genomics, analysis of changes in transcriptomic gene expression, revealing epigenetic effects on tissue and organ development, and heterogeneity at the single-cell level, among others. We present ...
By CD Genomics
-
The Link Between Smoking and Cognitive Decline
By now, you are likely aware of many of the well-established risks associated with smoking cigarettes, such as cancer, asthma, chronic obstructive pulmonary disease (COPD), diabetes, cardiovascular disease, and stroke. But did you know that research has discovered a link between smoking and cognitive decline? This research emphasizes the importance of identifying and controlling modifiable risk ...
-
Using AI to Fight a Pandemic: Insilico Medicine Announces Novel Preclinical Candidate for COVID-19 Treatment
Insilico Medicine announced the nomination of a novel preclinical therapeutic candidate for treating COVID-19, designed using the generative chemistry AI platform Chemistry42. The new drug candidate is a 3CL protease inhibitor unique from existing drugs in its class because it can be rapidly produced. While this nomination is a potentially important development for the ongoing COVID-19 pandemic ...
-
What Are Heparins?
Heparin, also known as standard heparin or unfractionated heparin, is a linear polysaccharide consisting of 1-4 linked disaccharide repeat units of uronic acid and glucosamine residues. Heparin was discovered nearly 100 years ago and has been used clinically as a blood anticoagulant since 1935. This is due to its ability to bind to the antithrombin(serine protease inhibitor), causing the ...
-
High Quality PEG Raw Materials From Biopharma PEG
Polyethylene glycol (PEG) is a polyether compound derived from petroleum with many applications, from industrial manufacturing to medicine. PEG is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), it has wide variety of applications depending on the length of the polymer chain and the molecular weight of the final polymer. The synthesis of PEG is done by polymerizing ethylene ...
-
Some Basic Facts about Forced Degradation Test for Drug Development
Benefits of forced degradation test The degradation pathway of the drug is closely related to the molecular structure of the drug. The ester group or amide bond in the molecular structure may be hydrolyzed under acid-base catalysis conditions. Provide support for drug safety. When toxicologically relevant impurities are not readily available, toxicological evaluation of samples degraded to a ...
-
Mitochondrial Proteomics
Mitochondria are important organelles of eukaryotic cells and play a key role in the regulation of cellular energy metabolism, biosynthesis and cell death (including apoptosis and programmed cell necrosis). In addition, mitochondria are involved in important physiological processes such as tricarboxylic acid cycle, fatty acid and amino acid oxidation, and regulation of calcium ion homeostasis. ...
-
VetStem Cell Therapy for Canine Cruciate Ligament Tears
Cruciate ligament rupture is one of the most common reasons for hind limb lameness, pain, and subsequent knee arthritis in dogs. Additionally, according to the American College of Veterinary Surgeons, 40-60% of dogs who injure one cruciate ligament will go on to injure the other cruciate ligament in the future. While there are multiple treatment options available, both surgical and non-surgical, ...
-
Research Shows a Link Between Loneliness and Dementia
Humans are inherently social beings who thrive on making and maintaining social relationships. Connecting with and supporting one another forms deep bonds that make us feel seen, valued, and like we belong. These social interactions are not only important for our emotional well-being but also for our physical well-being-maybe even more so than originally thought. Loneliness, an increasingly ...
-
OneThree’s Workflow for Identifying Synergistic Drug Combinations - Case study
Background OneThree Biotech was born out of the largest precision medicine institute in America with the purpose of decreasing the failure rate of bringing therapeutics to market using biology driven artificial intelligence. Our technology was builtin a lab setting; allowing us to engineer our methodologies around real-world results. While working with major biotech and pharma partners; ...
Need help finding the right suppliers? Try XPRT Sourcing. Let the XPRTs do the work for you