Pre-Clinical Articles
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Supporting Veterinary Resilience for World Veterinary Day
April 30th is World Veterinary Day. Taking place each year on the last Saturday of April, World Veterinary Day was created in 2000 by the World Veterinary Association as an annual celebration of the veterinary profession. Each year, there is a new theme. You can read about last year’s theme here. This year, the theme is Strengthening Veterinary Resilience. ...
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In the NFL `Afterlife` everything hurts
Not too long ago in the August 4th version of the San Jose Mercury News, reporter Elliott Almond caught up with NFL Hall-of-Fame quarterback Jim Plunkett to talk about life after football. His response made headlines. "My life sucks", said Plunkett, now 69. "It’s no fun being in this body right now. Everything hurts." The years of daily pain pulsating from the neck, back, knees, ...
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Pain and the Endocannabinoid System, A Physicians Perspective
The topic of pain and pain control is a very complex one with many different areas of concern and consideration. I will try to outline this complex topic as it applies to the endocannabinoid system. In my last article I briefly outlined this system and described it as an internal “buffer” the main function of which is to create homeostasis within our body. When considering the ...
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The Endocannabinoid System, A Physician`s Perspective
Most physicians are constantly learning not only for their benefit but, more importantly, for the benefit of their patients. It is not surprising therefore that there is considerable interest in the endocannabinoid system (ECS) as this system has only been recently recognized and appreciated. I think it is fair to say that over the last decade there has been more interest in the ECS than any ...
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Silk Fibroin Enhances Tendon Repair and Tissue Regeneration
Researchers at the Terasaki Institute for Biomedical Innovation have used silk protein, which is produced by silkworms, as a biomaterial for tendon repair. The researchers report that their approach has made significant progress in tendon regeneration of mesenchymal stem cells (MSCs). SF is a promising biomaterial for tendon repair, but its relatively rigid mechanical properties and low cell ...
By Matexcel
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How Much Do You Know about Bacteriocin?
In recent years, the increase in the number of multi-drug resistant pathogens and food safety have become serious global problems, and it is increasingly important to find or develop a new generation of antibacterial drugs or preservatives. Scientists have discovered that bacteria-produced bacteriocins can control clinically relevant susceptible and resistant bacteria, and purified bacteriocins ...
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Targeting Interleukin-6 Helps to Mitigate the Side Effects of Immunotherapy
Researchers at The University of Texas MD Anderson Cancer Center have identified a new strategy to reduce immune-related adverse events by targeting immunotherapy with the cytokine interleukin-6 (IL-6). The study, published in Cancer Cell, provides evidence for the concept of combining immune checkpoint blockers and cytokine blockers to selectively inhibit inflammatory autoimmune responses. ...
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A Novel Potential Target for CAR-T Cell Therapy in Human Solid Tumors Discovered
At present, chimeric antigen receptor T cell therapy (CAR-T) has made significant achievements in the treatment of specific hematological cancers, allowing patients with relapsed/refractory disease to survive longer and become healthier, but in clinical studies, cell therapy has actually not been successful in the treatment of patients with solid tumors, in part due to the lack of tumor targets ...
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Near-atomic-level Details of Cancer Proteins with the Help of Molecular Cages Revealed
Sandwiching the wobble protein between two other layers allowed scientists to get the most detailed picture of a protein that is key to the spread of acute myeloid leukemia. Acute myeloid leukemia (AML) afflicts more than 20,000 Americans each year, killing more than 11,000 of them, according to the American Cancer Institute. And many people who receive intensive chemotherapy or stem cell ...
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Mutation-directed Neo-protein-protein Interactions in Cancer
Genetic mutations in cells are an important cause of cancer development, progression, and drug resistance. How to quickly and accurately translate massive tumor genomic information into safe and effective cancer targeted therapies in clinical practice is a scientific frontier today. At present, a large number of scientific studies have focused on how oncogenic mutations regulate the activity of ...
By Profacgen
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Bioinformatics Analysis Brings Disease Genomics Research to a Crossroads
Introduction Since the completion of the Human Genome Project, genomics has played an increasingly critical role in the biomedical field. Its applications include variation and risk assessment in disease genomics, analysis of changes in transcriptomic gene expression, revealing epigenetic effects on tissue and organ development, and heterogeneity at the single-cell level, among others. We present ...
By CD Genomics
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LncRNA Sequencing Helps to Find Deep Links to Disease
Long non-coding RNAs (lncRNAs) are a class of RNAs that do not code for proteins and are typically greater than 200 nucleotides in length. Studies have shown that lncRNAs are quite complex in function and play an important role in various biological processes such as development, differentiation, proliferation, metastasis, apoptosis, stem cell pluripotency, and DNA damage. Therefore, those ...
By CD Genomics
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AI Designed Mutation Resistant Broad Neutralization Antibodies Against Multiple SARS-CoV-2 Strains based on A Digital Twin of COVID-19 - Case study
Introduction The emerging variants including Delta and Omicron may not retain activity with current available mAb products that were developed during the initial outbreak with the B.l strain. In this study, we have applied AI technologies in the computational design of broad neutralization antibodies against over 1300 different historical SARS-CoV-2 strains with very small computational cost. ...
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The Link Between Smoking and Cognitive Decline
By now, you are likely aware of many of the well-established risks associated with smoking cigarettes, such as cancer, asthma, chronic obstructive pulmonary disease (COPD), diabetes, cardiovascular disease, and stroke. But did you know that research has discovered a link between smoking and cognitive decline? This research emphasizes the importance of identifying and controlling modifiable risk ...
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Huateng Pharma Supplies Canagliflozin Intermediates With Commercial Scale Production
Canagliflozin is a medication used to treat type 2 diabetes. It is a third-line medication to be tried after metformin, a first-line medication for type 2 diabetes. It is used together with exercise and diet. It is not recommended in type 1 diabetes. Mechanism action of Canagliflozin Canagliflozin is a sodium-glucose cotransporter (SGLT2) inhibitor. Glucose filtered in the renal tubular lumen is ...
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How does your Vaginal Microbiome Affect your Cancer Risk?
When you hear about the vaginal microbiome (VMB), your first thought may be the role it plays in stuff like yeast infections or bacterial vaginosis (BV). But with improved research, we’re uncovering more of the VMB’s long-term effects, like its role in a healthy pregnancy and delivery. The complex community of organisms living in your vagina even plays a part in your risk of ...
By Juno Bio
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Types Of Smart Sensors For Agriculture
Types Of Smart Sensors For Agriculture Rapid social development, climate change, reduced rainfall and increased demand for food have all had a big impact on agriculture. This has had a negative impact on traditional farming practices. It is understood that we will be equipped with smart sensors in the agricultural sector.The current situation wants farming to become more “smart” by using modern ...
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What Are Heparins?
Heparin, also known as standard heparin or unfractionated heparin, is a linear polysaccharide consisting of 1-4 linked disaccharide repeat units of uronic acid and glucosamine residues. Heparin was discovered nearly 100 years ago and has been used clinically as a blood anticoagulant since 1935. This is due to its ability to bind to the antithrombin(serine protease inhibitor), causing the ...
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90+ reasons to smile
What happens when you bring 90+ expert dentistry and maxillofacial surgeon’s together in a room to unpack the burgeoning world of collagen membrane technology and digital dentistry? There are plenty of reasons to smile, that’s what. On Tuesday 7 August 2018, Australian regenerative medicine company Orthocell (ASX:OCC) sponsored and participated in an industry forum, Advances in ...
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The benefits of moving from traditional to condition-based electrical asset maintenance
The world’s largest soluble coffee factory, a Nestlé Nescafé plant located in Toluca, Mexico, was looking to eliminate unplanned stoppages and better understand its production efficiency. The factory operates 24 hours a day, year-round, and any stoppage impacts the reliability of production processes. Such interruptions also can affect the quality of the product that makes its ...
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